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Walter Korfmacher A. Mass Spectrometry for Drug Discovery and Development


Facilitates the discovery and development of new, effective therapeutics With coverage of the latest mass spectrometry technology, this book explains how mass spectrometry can be used to enhance almost all phases of drug discovery and drug development, including new and emerging applications. The book's fifteen chapters have been written by leading pharmaceutical and analytical scientists. Their contributions are based on a thorough review of the current literature as well as their own experience developing new mass spectrometry techniques to improve the ability to discover and develop new and effective therapeutics. Mass Spectrometry for Drug Discovery and Drug Development begins with an overview of the types of mass spectrometers that facilitate drug discovery and development. Next it covers: HPLC–high-resolution mass spectrometry for quantitative assays Mass spectrometry for siRNA Quantitative analysis of peptides Mass spectrometry analysis of biological drugs Applications that support medicinal chemistry investigations Mass spectrometry imaging and profiling Throughout the book, detailed examples underscore the growing role of mass spectrometry throughout the drug discovery and development process. In addition, images of mass spectra are provided to explain how results are interpreted. Extensive references at the end of each chapter guide readers to the primary literature in the field. Mass Spectrometry for Drug Discovery and Drug Development is recommended for readers in pharmaceutics, including medicinal chemists, analytical chemists, and drug metabolism scientists. All readers will discover how mass spectrometry can streamline and advance new drug discovery and development efforts.

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P. Fackler Mark The Handbook of Media and Mass Communication Theory


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Flamini Riccardo Mass Spectrometry in Grape and Wine Chemistry


A concise, up-to-date overview of the applications of mass spectrometry To be able to estimate the potentiality of grapes and how it may be transferred into wine is key to grasping enological chemistry. Nowadays, mass spectrometry is a crucial aspect in ensuring the production, the quality, and the safety of grape, wine, and grape derivative products. Mass Spectrometry in Grape and Wine Chemistry examines in depth the relationship between the high structural identification power of mass spectrometry techniques and the chemistry of grapes and wine. The text is divided into two parts. The first section provides an overview of mass spectrometry methods in relation to enology in three chapters. The second section offers seven chapters on wine chemistry as well as traditional topics and new developments in mass spectrometry. Mass Spectrometry in Grape and Wine Chemistry explores many mass spectrometry applications, including: Ionization methods Mass analyzers and mass measurements Mass spectrometry methodologies Grape aroma compounds Volatile and aroma compounds in wines Grape and wine polyphenols Compounds released by wood into wine Wine defects caused by compounds Pesticide detection analysis Peptides and proteins of grape and wine Written by leading experts in the field, this book presents an introduction to mass spectrometry and outlines ways to maximize quality control and product safety for the best results. Mass Spectrometry in Grape and Wine Chemistry is an essential handbook for laboratories working in enology.

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Stepan Podzimek Light Scattering, Size Exclusion Chromatography and Asymmetric Flow Field Fractionation. Powerful Tools for the Characterization of Polymers, Proteins Nanoparticles


A comprehensive, practical approach to three powerful methods of polymer analysis and characterization This book serves as a complete compendium of three important methods widely used for the characterization of synthetic and natural polymers—light scattering, size exclusion chromatography (SEC), and asymmetric flow field flow fractionation (A4F). Featuring numerous up-to-date examples of experimental results obtained by light scattering, SEC, and A4F measurements, Light Scattering, Size Exclusion Chromatography and Asymmetric Flow Field Flow Fractionation takes an all-in-one approach to deliver a complete and thorough explanation of the principles, theories, and instrumentation needed to characterize polymers from the viewpoint of their molar mass distribution, size, branching, and aggregation. This comprehensive resource: Is the only book gathering light scattering, size exclusion chromatography, and asymmetric flow field flow fractionation into a single text Systematically compares results of size exclusion chromatography with results of asymmetric flow field flow fractionation, and how these two methods complement each other Provides in-depth guidelines for reproducible and correct determination of molar mass and molecular size of polymers using SEC or A4F coupled with a multi-angle light scattering detector Offers a detailed overview of the methodology, detection, and characterization of polymer branching Light Scattering, Size Exclusion Chromatography and Asymmetric Flow Field Flow Fractionation should be of great interest to all those engaged in the polymer analysis and characterization in industrial and university research, as well as in manufacturing quality control laboratories. Both beginners and experienced can confidently rely on this volume to confirm their own understanding or to help interpret their results.

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Naeemah Clark Diversity in U.S. Mass Media


An updated edition of the comprehensive resource that covers the various areas associated with representations of diversity within the mass media The second edition of Diversity in U.S. Mass Media presents a review of the evolution and the many issues surrounding portrayals of social groups in the mass media of the United States. Unfortunately, all too often mass media depictions play a crucial role in shaping our views about individuals and social groups. Filled with instructive insights into the ways social groups are represented through the mass media, Diversity in U.S. Mass Media offers a better understanding of groups and individuals different from ourselves. The revised second edition is filled with recent, illustrative examples from the media. Comprehensive in scope, the authors address a wide range of issues that include representations of race/ethnicity, gender, sexual orientation, disability, class, and religion in films, television, and the press. The authors encourage readers to question what is being presented and explore the extent to which they agree with the perspectives that are described. Diversity in U.S. Mass Media is an important resource that: Offers an understanding of how various social groups are being represented in the mass media Explores how diverse communities inform and intersect with one another Draws on updated studies on the topic and presents original research and observations Includes new chapters on media portrayals of mixed race relationships and multiracial/multiethnic people and representations of religion and faith Accompanied by a companion website for instructors including many useful pedagogical tools, such as a test bank, viewing list, exercises, and sample syllabi Revised and updated, the second edition of Diversity in U.S. Mass Media offers a broad perspective on the myriad issues that influence how the media portrays social groups. Throughout the text, the authors show consistencies as well as differences in media representations of minority groups in the United States.

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